Active ingredients: paracetamol 500 mg, caffeine 65 mg.

Excipients: pregelatinized starch - 50 mg, corn starch - 41.4 mg, povidone (K22.5-27.0) - 2 mg, potassium sorbate - 0.6 mg, talc - 15 mg, stearic acid - 5 mg, croscarmellose sodium - 10 mg, hypromellose - 5 mg, triacetin - 1 mg.

An analgesic-antipyretic combined composition, contains a combination of two active ingredients: paracetamol and caffeine. It has antipyretic and analgesic effects.

Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of the anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues leads to the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.

Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.

 

Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract, the distribution in body fluids is relatively even. The binding of paracetamol to plasma proteins is minimal at a therapeutic concentration.

Paracetamol is metabolized in the liver and excreted in the urine as glucuronide and sulfate metabolites - less than 5% is excreted unchanged. T1 / 2 when taking a therapeutic dose is 2-3 hours.

Caffeine is rapidly absorbed from the digestive tract and distributed throughout the body. Caffeine is almost completely metabolized in the liver by oxidation and demethylation in the form of metabolites, which are excreted in the urine. T1 / 2 is 4-9 hours.

 

Solpadein Fast soluble tablets before ingestion should be dissolved in at least 100 ml (half a glass) of water.

Adults (including the elderly) and children over 12 years old are prescribed 1-2 tablets. 3-4 times / day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

The drug is not recommended to be used for more than five days as an analgesic and for more than three days as an antipyretic without the appointment and supervision of a doctor.

An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

- severe liver dysfunction;

- severe renal dysfunction;

- arterial hypertension;

- glaucoma;

- sleep disorders;

- epilepsy;

- children under 12 years old;

- hypersensitivity to the components of the drug.

The drug should be used with caution in benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, glucose-6-phosphate dehydrogenase deficiency, alcoholism.

Carefully:

- severe liver dysfunction;

- severe renal dysfunction;

- children under 12 years of age.

Application is possible according to the dosage regimen.

Application during pregnancy and lactation:

Solpadein Fast contains caffeine. When taking caffeine, there is a high risk of having a low birth weight baby, the risk of spontaneous abortion.

Caffeine in breast milk may have a stimulating effect on a breastfed baby.

Solpadein Fast should not be used during pregnancy and lactation (breastfeeding).