Buy Salbutamol online. Free worldwide shipping.
Brand: Binnopharm
Drug form:
Aerosol for inhalation dosed in the form of a suspension of white or almost white color.
Manufacturers: Russia
Active substance: Salbutamol
Group: Bronchodilator - beta2-adrenergic agonist
Expiration date: 3 years
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Salbutamol aerosol for inhalation 12ml
Indications for use of Salbutamol are:
Bronchial asthma: relief of symptoms of bronchial asthma when they occur; prevention of bouts of bronchospasm associated with exposure to an allergen or caused by exercise; use as one of the components in long-term maintenance therapy of bronchial asthma. Other chronic lung diseases with reversible airway obstruction, including COPD, chronic bronchitis, pulmonary emphysema.
Pharmachologic effect:
Beta-adrenomimetic with a predominant effect on β2-adrenergic receptors. In therapeutic doses, salbutamol acts on β2-adrenergic receptors of the smooth muscles of the bronchi and has a short (4 to 6 hours) bronchodilatory effect on β2-adrenergic receptors with a rapid onset of action (within 5 minutes) with reversible airway obstruction. Prevents and relieves bronchospasm; reduces resistance in the airways, increases the vital capacity of the lungs. Prevents the release of histamine, a slow-reacting substance from mast cells and neutrophil chemotaxis factors. Increases mucociliary clearance (in chronic bronchitis up to 36%), stimulates mucus secretion, activates the functions of the ciliated epithelium. In recommended therapeutic doses, it does not adversely affect the cardiovascular system, does not cause an increase in blood pressure. To a lesser extent, in comparison with drugs of this group, it has a positive chrono- and inotropic effect on the myocardium. Causes expansion of the coronary arteries. It has a number of metabolic effects: it reduces the concentration of potassium in the blood plasma, affects glycogenolysis and insulin secretion, has hyperglycemic (especially in patients with bronchial asthma) and lipolytic effects, increases the risk of acidosis.
Pharmacokinetics:
During inhalation, 10-20% of the dose reaches the small bronchi, the rest is deposited in the upper respiratory tract. The fraction deposited in the respiratory tract is absorbed into the lung tissue and blood, but is not metabolized in the lungs. After inhalation use, systemic absorption is fast, but low. Cmax of salbutamol in blood plasma is observed after 3 hours. After oral administration, salbutamol is well absorbed from the gastrointestinal tract. Plasma protein binding is 10%. Metabolized during the "first pass" through the liver and possibly in the intestinal wall; the main metabolite is an inactive sulfate conjugate. Salbutamol is not metabolized in the lungs, so its final metabolism and excretion after inhalation depends on the route of administration, which determines the ratio between inhaled and unintentionally swallowed salbutamol. T1 / 2 from blood plasma is 3-7 hours. It is excreted by the kidneys, mainly unchanged (about 90%) and in the form of an inactive phenolsulfate metabolite (about 60%) within 72 hours, and with bile. Salbutamol penetrates the BBB, creating concentrations equal to approximately 5% of the concentration in blood plasma.