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Buy PARACETAMOL 500mg 20tabs online. Free worldwide shipping. PayPal payment.

Brand: Ozone

Drug form: Tablet

Manufacturers: Russia

Active substance: Paracetamol

Group: Analgesic antipyretic

Expiration date: 2 years

PARACETAMOL 500mg 20tabs

SKU: 51
$17.00Price
  •  Indications for use of Paracetamol are:

    Pain syndrome of weak and moderate intensity of various origins (including headache, migraine, toothache, neuralgia, myalgia, algomenorrhea; pain in case of injuries, burns). Fever in infectious and inflammatory diseases.

      Pharmachologic effect:

    Analgesic antipyretic. It has analgesic, antipyretic and weak anti-inflammatory effects. The mechanism of action is associated with inhibition of prostaglandin synthesis, a predominant effect on the center of thermoregulation in the hypothalamus.

    Pharmacokinetics:

    After oral administration, paracetamol is rapidly absorbed from the gastrointestinal tract, mainly in the small intestine, mainly by passive transport. After a single dose of 500 mg, Cmax in blood plasma is achieved after 10-60 minutes and is about 6 μg / ml, then gradually decreases and after 6 hours is 11-12 μg / ml.

    It is widely distributed in tissues and mainly in body fluids, with the exception of adipose tissue and cerebrospinal fluid.

    Protein binding is less than 10% and slightly increases in case of overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even in relatively high concentrations.

    Paracetamol is metabolized mainly in the liver by conjugation with glucuronide, conjugation with sulfate and oxidation with the participation of mixed liver oxidases and cytochrome P450.

    A hydroxylated metabolite with a negative effect, N-acetyl-p-benzoquinone imine, which is formed in very small quantities in the liver and kidneys under the influence of mixed oxidases and is usually detoxified by binding to glutathione, can accumulate with paracetamol overdose and cause tissue damage.

    In adults, most of paracetamol binds to glucuronic acid and to a lesser extent to sulfuric acid. These conjugated metabolites have no biological activity. In premature babies, newborns and in the first year of life, the sulfate metabolite predominates.

    T1 / 2 is 1-3 hours. In patients with liver cirrhosis, T1 / 2 is slightly higher. The renal clearance of paracetamol is 5%.

    It is excreted in the urine mainly in the form of glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol.

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