Buy Nimesil granules for suspension preparation 100mg 2g No. 30 online. Free worldwide shipping.
Brand: Rompharm
Drug form: Suspension granules
Manufacturers: Romania
Active substance: Nimesulide
Group: Anti-inflammatory drugs of different groups
Expiration date: 2 years
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NIMESIL granules for suspension preparation 100mg 2g No. 30
Indications for use of Nimesil are:
Acute pain (back pain, lower back pain; pain in the musculoskeletal system, including bruises, sprains and dislocations of the joints; tendinitis, bursitis; toothache); symptomatic treatment of osteoarthritis (osteoarthritis) with pain syndrome; primary algomenorrhea. The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use; Nimesulide is recommended for therapy as a second-line drug.
Pharmachologic effect:
Pharmacodynamics. Nimesulide is a non-steroidal anti-inflammatory drug from the sulfonamide class. It has anti-inflammatory, analgesic and antipyretic effects. Unlike non-selective NSAIDs, nimesulide mainly inhibits cyclooxygenase-2 (COX-2), inhibits the synthesis of prostaglaidins in the inflammation focus; has a less pronounced inhibitory effect on cyclooxygenase-1 (COX-1). Pharmacokinetics. Nimesulide is well absorbed from the gastrointestinal tract (GIT). The maximum concentration in blood plasma after oral administration of a single dose of nimesulide, which is 100 mg, is reached on average after 2 to 3 hours and is 3-4 mg / l. The area under the concentration-time curve (AUC) is 20-35 mg h / l. Communication with blood plasma proteins - up to 97.5%. It is metabolized in the liver by the cytochrome P450 isoenzyme (CYP) 2C9. The main metabolite is the pharmacologically active parahydroxy derivative of nimesulide - hydroxynimesulide, which is found exclusively in the form of glucuronate. Nimesulide is excreted from the body mainly in the urine (about 50% of the dose taken), in the metabolized form, about 29% is excreted in the feces. The half-life is 3.2-6 hours. The pharmacokinetic profile of iimesulide in the elderly and in patients with renal insufficiency of mild to moderate severity of ns changes with the use of single and multiple / repeated doses. In a study conducted in patients with renal insufficiency of mild to moderate severity (creatinine clearance 30-80 ml / min), the maximum concentration of iimesulide and its main metabolite were not higher than in healthy volunteers. AUC and half-life were 50% higher, but were within the AUC and T '/ 2 values observed in healthy volunteers while using iimesulide. Repeated use did not lead to the cumulation of nimesulide.