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Buy Metformin online. Free worldwide shipping. 

Brand: Nycomed

Drug form: Tablet

Manufacturers: NYCOMED AUSTRIA GmbH.

Active substance: Metformin hydrochloride

Group: Pharmacological action - hypoglycemic

Expiration date: 2 years

 

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METFORMIN (Fortamet, Glucophage, Glumetz) IR-XR, 500-1000 mg/tab, 30-60 tabs

$23.00Price
Out of Stock
  • Indications for use of Metformin are:

    Diabetes mellitus type 2 (non-insulin dependent) with ineffectiveness of diet therapy and exercise, in obese patients: in adults - as monotherapy or in combination with other oral hypoglycemic agents or with insulin; in children aged 10 years and older - as monotherapy or in combination with insulin.

    Pharmachologic effect:

    Oral hypoglycemic agent from the biguanide group (dimethylbiguanide). The mechanism of action of metformin is associated with its ability to suppress gluconeogenesis, as well as the formation of free fatty acids and fat oxidation. Increases the sensitivity of peripheral receptors to insulin and glucose utilization by cells. Metformin does not affect the amount of insulin in the blood, but changes its pharmacodynamics by reducing the ratio of bound insulin to free and increasing the ratio of insulin to proinsulin.

    Metformin stimulates glycogen synthesis by acting on glycogen synthetase. Increases the transport capacity of all types of membrane glucose transporters. Delays the absorption of glucose in the intestine.

    Reduces the level of triglycerides, LDL, VLDL. Metformin improves the fibrinolytic properties of blood by suppressing tissue-type plasminogen activator inhibitor.

    While taking metformin, the patient's body weight either remains stable or moderately decreases.

      Pharmacokinetics:

    After oral administration, metformin is slowly and incompletely absorbed from the gastrointestinal tract. C max in plasma is reached after about 2.5 hours. With a single dose of 500 mg, the absolute bioavailability is 50-60%. With the simultaneous intake of food, the absorption of metformin is reduced and delayed.

    Metformin is rapidly distributed into body tissues. Practically does not bind to plasma proteins. It accumulates in the salivary glands, liver and kidneys.

    It is excreted by the kidneys unchanged. T1 / 2 from plasma is 2-6 hours.

    In case of impaired renal function, accumulation of metformin is possible.

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