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Buy Concor tablets 5mg, 10mg  No. 30 online. Free worldwide shipping. 

Brand: Merck KGaA 

Drug form: Tablets

Manufacturers: Merck KGaA (Germany)

Active substance: Bisoprolol hemifumarate (bisoprolol fumarate (2:1)

Group: Beta1-blockers (cardioselective)

Expiration date: 3 years

 

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CONCOR tablets 5mg, 10mg  No. 30

$25.00Price
Out of Stock
  • Indications for use of Concor are:

    Arterial hypertension; ischemic heart disease: stable angina pectoris; chronic heart failure.

    Pharmachologic effect:

    Pharmacodynamics. Selective beta1 - adrenergic blocker, without its own sympathomimetic activity, does not have a membrane stabilizing effect. It has only a slight affinity for beta2-adrenergic receptors of the smooth muscles of the bronchi and blood vessels, as well as for beta2-adrenergic receptors involved in the regulation of metabolism. Therefore, bisoprolol does not generally affect airway resistance and metabolic processes in which beta2-adrenergic receptors are involved. The selective effect of the drug on beta1-adrenergic receptors persists beyond the therapeutic range. With a single use in patients with ischemic heart disease (IHD) without signs of chronic heart failure (CHF), bisoprolol reduces the heart rate (HR), stroke volume and, as a consequence, reduces the ejection fraction and myocardial oxygen demand. With long-term therapy, the initially increased total peripheral vascular resistance (OPSS) decreases. Pharmacokinetics. Suction. Bisoprolol is almost completely (more than 90%) absorbed from the gastrointestinal tract. Its bioavailability due to insignificant metabolism "at first pass" through the liver (at about 10%) is about 90% after oral administration. Food intake does not affect bioavailability. Bisoprolol demonstrates linear kinetics, and its plasma concentrations are proportional to the dose taken in the range from 5 to 20 mg. The maximum concentration in blood plasma is reached after 2-3 hours. Distribution. Bisoprolol is widely distributed. The volume of distribution is 3.5 l / kg. The connection with blood plasma proteins reaches approximately 30%. Metabolism. It is metabolized by the oxidative pathway without subsequent conjugation. All metabolites are polar (water-soluble) and are excreted by the kidneys. The main metabolites found in blood plasma and urine do not show pharmacological activity. The data obtained as a result of experiments with human liver microsomes in vitro show that bisoprolol is metabolized primarily by the CYP3A4 isoenzyme (about 95%), and the CYP2D6 isoenzyme plays only a small role. Excretion. The clearance of bisoprolol is determined by the balance between excretion by the kidneys unchanged (about 50%) and metabolism in the liver (about 50%) to metabolites, which are then also excreted by the kidneys. The total ground clearance is 15 l / h. The half-life is 10-12 hours. There is no information on the pharmacokinetics of bisoprolol in patients with CHF and simultaneous impaired liver or kidney function.

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