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Buy Cipralex (Escitalopram) 10mg N14. online. Free worldwide shipping. 

Brand: Lundbeck

Drug form: Escitalopram

Manufacturers: Denmark

Active substance: Escitalopram

Group: Antidepressant

Expiration date: 3 years

 

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CIPRALEX (Escitalopram) 10mg N14

SKU: 39
$54.00Price
  •   Indications for use of Cipralex (Escitalopram) are:

    • depressive episodes of any severity;
    • panic disorder with or without agoraphobia;
    • social anxiety disorder (social phobia);
    • generalized anxiety disorder;
    • obsessive-compulsive disorder.

      Pharmachologic effect:

    Cipralex has an antidepressant effect.

      Pharmacodynamics:

    Escitalopram is an antidepressant, SSRI, with high affinity for the primary binding site. Escitalopram also binds to the allosteric binding site of the transporter protein, with a thousand-fold lower affinity. Allosteric modulation of the transporter protein enhances the binding of escitalopram at the primary binding site, which leads to a more complete inhibition of serotonin reuptake.

    Escitalopram has no or very weak ability to bind to a number of receptors, including: serotonin 5-HT1A-, 5-HT2 receptors, dopamine D1 and D2 receptors, α1-, α2-, β-adrenergic receptors, histamine H1 receptors , m-cholinergic receptors, benzodiazepine and opioid receptors.

      Pharmacokinetics:

    Absorption is almost complete and does not depend on food intake. The average Tmax in blood plasma is 4 hours after repeated use. The absolute bioavailability of escitalopram is about 80%.

    The apparent Vd after oral administration is between 12 and 26 L / kg. The binding of escitalopram and its main metabolites with blood plasma proteins is below 80%.

    Escitalopram is metabolized in the liver to demethylated and didemethylated metabolites. They are both pharmacologically active. Nitrogen can be oxidized to an N-oxide metabolite. The main substance and its metabolites are partially excreted in the form of glucuronides. After repeated use, the average concentration of demethyl- and didemethyl-metabolites is usually 28–31% and less than 5%, respectively, of the escitalopram concentration. Biotransformation of escitalopram into a demethylated metabolite occurs mainly with the help of the isoenzyme CYP2C19. Some involvement of the isoenzymes CYP3A4 and CYP2D6 is possible. In individuals with a weak activity of the isoenzyme CYP2C19, the concentration of escitalopram is two times higher than in cases with a high activity of this isoenzyme. Significant changes in the concentration of the drug in cases with weak activity of the isoenzyme CYP2D6 were not found.

    T1 / 2 after repeated use is about 30 hours. Clearance for oral administration is about 0.6 l / min. The main metabolites of escitalopram have a longer half-life. Escitalopram and its main metabolites are excreted by the liver (metabolic pathway) and kidneys; most of it is excreted in the form of metabolites in the urine.

    The kinetics of escitalopram is linear. Equilibrium concentration is reached after about 1 week. Average Css, 50 nmol / L (20 to 125 nmol / L), is achieved with a daily dose of 10 mg.

    Special patient groups

    Patients over 65. In the elderly, escitalopram is excreted more slowly than in younger patients. The amount of a substance in the systemic circulation, calculated using the pharmacokinetic index AUC, in the elderly is 50% higher than in young healthy volunteers.

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