The tablets should be swallowed whole with water. If desired, the tablet can be broken in half, chewed or pre-ground.

For the primary prevention of cardiovascular diseases, such as thrombosis and acute heart failure in the presence of risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age), 1 tab is prescribed. Cardiomagnet containing acetylsalicylic acid at a dose of 150 mg on the first day, then 1 tab. Cardiomagnet containing acetylsalicylic acid at a dose of 75 mg 1 time / day.

For the prevention of recurrent myocardial infarction and thrombosis of blood vessels, 1 tab is prescribed. Cardiomagnet containing acetylsalicylic acid at a dose of 75-150 mg 1 time / day.

For the prevention of thromboembolism after surgical interventions on the vessels (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty), 1 tab is prescribed. Cardiomagnet containing acetylsalicylic acid at a dose of 75-150 mg 1 time / day.

With unstable angina pectoris, 1 tab is prescribed. Cardiomagnet containing acetylsalicylic acid at a dose of 75-150 mg 1 time / day.

• hemorrhage in the brain;
• tendency to bleeding (vitamin K deficiency, thrombocytopenia, hemorrhagic diathesis);
• bronchial asthma induced by the intake of salicylates and NSAIDs;
• erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
• gastrointestinal bleeding;
• severe renal failure (CC <10 ml / min);
• deficiency of glucose-6-phosphate dehydrogenase;
• concomitant use with methotrexate (> 15 mg per week);
• I and III trimesters of pregnancy;
• lactation period (breastfeeding);
• children and adolescents up to 18 years old;
• hypersensitivity to acetylsalicylic acid, excipients of the drug and other NSAIDs.

With caution, the drug should be prescribed for gout, hyperuricemia, a history of ulcerative lesions of the gastrointestinal tract or bleeding from the gastrointestinal tract, with renal and / or liver failure, bronchial asthma, hay fever, nasal polyposis, allergic conditions, in the II trimester of pregnancy.

Application during pregnancy and lactation:

The use of salicylates in high doses in the first trimester of pregnancy is associated with an increased incidence of fetal defects. In the second trimester of pregnancy, salicylates can only be prescribed with a rigorous assessment of the risks and benefits. In the third trimester of pregnancy, salicylates in a high dose (> 300 mg / day) cause inhibition of labor, premature closure of the ductus arteriosus in the fetus, increased bleeding in the mother and fetus, and administration just before childbirth can cause intracranial hemorrhage, especially in premature babies. The appointment of salicylates in the third trimester of pregnancy is contraindicated.

The available clinical data are insufficient to establish the possibility or impossibility of using the drug during breastfeeding. Before prescribing acetylsalicylic acid during breastfeeding, the potential benefit of drug therapy should be evaluated relative to the potential risk to infants.

Application for violations of liver function:

In case of hepatic insufficiency, use with caution.

Application for impaired renal function:

The drug is contraindicated in severe renal failure (CC less than 10 ml / min); in renal failure, use with caution.

Application in children:

Contraindicated in children and adolescents under 18 years of age.

The frequency of the adverse reactions listed below was determined according to the following: very often (≥1 / 10); often (> 1/100, <1/10); sometimes (> 1/1000, <1/100); rarely (> 1/10 000, <1/1000); very rare (<1/10 000, including individual reports).

Allergic reactions: often - urticaria, Quincke's edema; sometimes - anaphylactic reactions.

From the digestive system: very often - heartburn; often - nausea, vomiting; sometimes - pain in the abdomen, ulcers of the mucous membrane of the stomach and duodenum, gastrointestinal bleeding; rarely - perforation of a stomach or duodenal ulcer, increased activity of liver enzymes; very rarely - stomatitis, esophagitis, erosive lesions of the upper gastrointestinal tract, strictures, colitis, irritable bowel syndrome.

From the respiratory system: often - bronchospasm.

From the side of the hematopoietic system: very often - increased bleeding; rarely - anemia; very rarely - hypoprothrombinemia, thrombocytopenia, neutropenia, aplastic anemia, eosinophilia, agranulocytosis.

From the side of the central nervous system: sometimes - dizziness, drowsiness; often - headache, insomnia; rarely - tinnitus, intracerebral hemorrhage.

With the simultaneous use of acetylsalicylic acid enhances the effect of the following drugs:

methotrexate (by reducing renal clearance and displacing it from the connection with proteins);

heparin and indirect anticoagulants (due to dysfunction of platelets and displacement of indirect anticoagulants from the connection with proteins);

thrombolytic and antiplatelet and anticoagulant drugs (ticlopidine);

digoxin (due to a decrease in its renal excretion);

hypoglycemic agents for oral administration (sulfonylurea derivatives) and insulin (due to the hypoglycemic properties of acetylsalicylic acid itself in high doses and the displacement of sulfonylurea derivatives from the connection with plasma proteins);

valproic acid (due to its displacement from the connection with proteins).

The simultaneous use of acetylsalicylic acid with ibuprofen leads to a decrease in the cardioprotective effects of acetylsalicylic acid.

An additive effect is observed with the simultaneous administration of acetylsalicylic acid with ethanol (alcohol).

Acetylsalicylic acid weakens the action of uricosuric agents (benzbromarone) due to the competitive tubular elimination of uric acid.

Enhancing the elimination of salicylates, systemic corticosteroids weaken their effect.

Antacids and colestyramine, when used simultaneously, reduce the absorption of Cardiomagnyl.

Overdose symptoms of moderate severity: nausea, vomiting, tinnitus, hearing impairment, dizziness, confusion.

Treatment: the stomach should be flushed, activated charcoal should be prescribed, symptomatic therapy should be carried out.

Overdose symptoms of a severe degree: fever, hyperventilation, ketoacidosis, respiratory alkalosis, coma, cardiovascular and respiratory failure, severe hypoglycemia.

Treatment: immediate hospitalization in specialized departments for emergency therapy - gastric lavage, determination of acid-base balance, alkaline and forced alkaline diuresis, hemodialysis, administration of saline solutions, activated carbon, symptomatic therapy. When carrying out alkaline diuresis, it is necessary to achieve pH values ​​between 7.5 and 8. Forced alkaline diuresis should be carried out when the concentration of salicylates in plasma is more than 500 mg / l (3.6 mmol / l) in adults and 300 mg / l (2.2 mmol / l) in children.