Adults take 1 tablet in the morning, with meals. Duration of admission is 1-2 months. If necessary, the reception can be repeated.

Individual intolerance to the components, pregnancy, breastfeeding, increased nervous irritability, insomnia, hypertension, cardiac dysfunction, severe atherosclerosis, admission in the evening. It is recommended to consult a doctor before use.

Application during pregnancy and lactation:

Contraindicated

No information available.

With simultaneous use, the effect of hypnotics and anesthetics decreases.

With simultaneous use, it is possible to enhance the action of analgesics-antipyretics, salicylamide, naproxen.

With the simultaneous use of estrogens (hormonal contraceptives, HRT agents), it is possible to increase the intensity and duration of the action of caffeine due to the inhibition of the CYP1A2 isoenzyme by estrogens.

With the simultaneous use of adenosine, caffeine reduces the increased heart rate and changes in blood pressure caused by the infusion of adenosine; reduces vasodilation caused by the action of adenosine.

With simultaneous use, it is possible to increase the bioavailability, absorption rate and plasma concentration of acetylsalicylic acid.

With the simultaneous use of mexiletine reduces the clearance of caffeine and increases its concentration in plasma, apparently due to the inhibition of caffeine metabolism in the liver by mexiletine.

Methoxalen reduces the excretion of caffeine from the body with a possible increase in its effect and the development of toxic effects.

The combined use of caffeine with beta-blockers can lead to mutual suppression of therapeutic effects.

Caffeine accelerates absorption and enhances the action of cardiac glycosides, increases their toxicity.

Due to the induction of liver microsomal enzymes under the influence of phenytoin, with its simultaneous use, the metabolism and excretion of caffeine are accelerated.

Fluconazole and terbinafine cause a moderate increase in the concentration of caffeine in the blood plasma, ketoconazole - less pronounced.

The most pronounced increase in AUC and decrease in clearance are observed with the simultaneous use of caffeine with enoxacin, ciprofloxacin, pipemidic acid; less pronounced changes - with pefloxacin, norfloxacin, fleroxacin.

With simultaneous use of caffeine accelerates the absorption of ergotamine.

When abused, caffeine (more than 300 mg per day, i.e. four cups of natural coffee, 150 ml each) can cause anxiety, anxiety, tremors, headache, confusion, cardiac extrasystoles. In newborns (including premature infants), at a plasma concentration of 50 mg / ml, toxic effects are possible: anxiety, tachypnea, tachycardia, tremor, increased Moro reflex, at higher concentrations - convulsions.