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Buy Atarax (Hydroxyzine) online. Free worldwide shipping. PayPal payment.

Brand: UCB Pharma, S.A.

Drug form: Tablets

Manufacturers: Belgium

Active substance: Hydroxyzine

Group: Tranquilizers of different groups

Expiration date: 5 years

 

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Atarax (Hydroxyzine) 25mg

$20.00Price
Out of Stock
  • Indications for use of Atarax (Hydroxyzine) are:

    Symptomatic treatment of anxiety in adults. As a sedative during premedication. Symptomatic treatment of allergic pruritus.

    Pharmachologic effect:

    Pharmacodynamics. A derivative of diphenylmethane, inhibits the activity of certain subcortical zones. It has H1-histamine blocking, bronchodilatory and antiemetic effects, has a moderate inhibitory effect on gastric secretion. Hydroxyzine significantly reduces itching in patients with urticaria, eczema and dermatitis. In hepatic insufficiency, the H1-histamine blocking effect can last up to 96 hours after a single dose. It has moderate anxiolytic activity and sedative effect. Polysomnography in patients with insomnia and anxiety demonstrates an increase in the duration of sleep, a decrease in the frequency of nocturnal awakenings after a single dose or repeated administration of hydroxyzine at a dose of 50 mg. A decrease in muscle tension in patients with anxiety was noted when taking the drug at a dose of 50 mg 3 times a day. Does not cause mental dependence and addiction. With long-term use, there was no “withdrawal” syndrome and no deterioration of cognitive functions. The H1-histamine blocking effect occurs approximately 1 hour after oral administration of the tablets. Sedation appears after 30-40 minutes. It has antispasmodic and sympatholytic effects, and also has a moderate analgesic effect. Pharmacokinetics. Suction. Absorption is high. The time to reach the maximum concentration after oral administration is 2 hours. After taking a single dose of 25 mg, the time to reach the maximum concentration in adults is 30 ng / ml and 70 ng / ml after taking 50 mg of hydroxyzine. Oral bioavailability is 80%. Distribution. Hydroxyzine is more concentrated in tissues than in plasma. The distribution coefficient is 7-16 l / kg in adults. After oral administration, hydroxyzine penetrates well into the skin, while the concentration of hydroxyzine in the skin is much higher than the concentration in the serum, both after a single dose and after multiple doses. Hydroxyzine crosses the blood-brain barrier and the placenta, concentrating to a greater extent in fetal than in maternal tissues. Metabolism. Hydroxyzine is metabolized in the liver. Cetirizine - the main metabolite (45%), is a blocker of peripheral H1-histamine receptors. Metabolites are found in breast milk. Excretion. The half-life in adults is 14 hours (range: 7-20 hours). The total clearance of hydroxyzine is 13 ml / min / kg. Only 0.8% of hydroxyzine is excreted unchanged through the kidneys. The main metabolite, cetirizine, is excreted mainly unchanged in the urine (25% of the taken hydroxyzine dose). Pharmacokinetics in special patient groups. In elderly patients. In elderly patients, the half-life was 29 hours, the volume of distribution is 22.5 l / kg. It is recommended to reduce the daily dose of hydroxyzine when administered to elderly patients. In children. In children, the total clearance is 2.5 times higher than in adults. The elimination half-life is shorter than in adults: 11 hours for children aged 14 years and 4 hours for children aged 1 year. The dose should be adjusted when used in children. In patients with hepatic impairment. In patients with secondary liver dysfunction due to primary biliary cirrhosis, the total clearance was approximately 66% of the value recorded in healthy volunteers. In patients with liver diseases, the half-life increased to 37 hours, the concentration of metabolites in the blood serum is higher than in young patients with normal liver function. For patients with hepatic impairment, a decrease in the daily dose or frequency of administration is recommended. In patients with renal insufficiency. The pharmacokinetics of hydroxyzine was studied using the example of 8 patients with severe renal failure (creatinine clearance 24 ± 7 ml / min). The duration of exposure to hydroxyzine (AUC (area under the curve)) did not change significantly, while the duration of exposure to the carboxylic metabolite, cetirizine, was increased. Hemodialysis is ineffective at removing this metabolite. To avoid any significant accumulation of the metabolite of cetirizine after repeated use of hydroxyzine, the daily dose of hydroxyzine should be reduced in patients with impaired renal function.

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