Buy Aspirin Cardio tablets 100mg No. 56 online. Free worldwide shipping.
Brand: BAYER, AG (Germany)
Drug form: Сoated tablets
Manufacturers: BAYER BITTERFELD, GmbH (Germany)
Active substance: Acetylsalicylic acid
Group: Anti-inflammatory drugs - derivatives of salicylic acid
Expiration date: 5 years
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ASPIRIN CARDIO tablets 100mg No. 56
Indications for use of Aspirin Cardio are:
Primary prevention of acute myocardial infarction in the presence of risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age) and repeated myocardial infarction; unstable angina (including suspected development of acute myocardial infarction) and stable angina; stroke prevention (including in patients with transient cerebrovascular accident); prevention of transient disorders of cerebral circulation; prevention of thromboembolism after surgery and invasive interventions on the vessels (for example, coronary artery bypass grafting, endarterectomy of the carotid arteries, arteriovenous bypass grafting, angioplasty and stenting of the coronary arteries, angioplasty of the carotid arteries); prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (including with prolonged immobilization as a result of extensive surgical intervention).
Pharmachologic effect:
Pharmacodynamics. The mechanism of the antiplatelet action of acetylsalicylic acid (ASA) is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. The antiplatelet effect is most pronounced in platelets, because they are unable to re-synthesize cyclooxygenase. It is believed that ASA has other mechanisms for suppressing platelet aggregation, which expands the scope of its application in various vascular diseases. ASA also has anti-inflammatory, analgesic and antipyretic effects. Pharmacokinetics. After oral administration, ASA is rapidly and completely absorbed from the gastrointestinal tract. ASA is partially metabolized during absorption. During and after absorption, ASA is converted into the main metabolite - salicylic acid, which is metabolized mainly in the liver under the influence of enzymes with the formation of such metabolites as phenyl salicylate, glucuronide salicylate and salicylic acid, found in many tissues and in urine. In women, the metabolic process is slower (less enzyme activity in the blood serum). The maximum concentration of ASA in blood plasma is reached 10-20 minutes after ingestion, salicylic acid - after 0.3-2 hours. Due to the fact that the tablets are coated with an acid-resistant membrane, ASA is released not in the stomach (the membrane effectively blocks the dissolution of the drug in the stomach) , and in the alkaline environment of the duodenum. Thus, the absorption of ASA in the form of enteric-coated tablets is slowed down by 3-6 hours compared to conventional (without such a coating) tablets. ASA and salicylic acid bind to blood plasma proteins (from 66% to 98% depending on the dose) and are rapidly distributed in the body. Salicylic acid crosses the placental barrier and is excreted in breast milk. The excretion of salicylic acid is dose-dependent, since its metabolism is limited by the capabilities of the enzymatic system. The half-life is from 2-3 hours when using ASA in low doses and up to 15 hours when using the drug in high doses (usual doses of acetylsalicylic acid as an analgesic). Unlike other salicylates, with repeated administration of the drug, non-hydrolyzed ASA does not accumulate in the blood serum. Salicylic acid and its metabolites are excreted by the kidneys. In patients with normal renal function, 80-100% of a single dose of the drug is excreted by the kidneys within 24-72 hours.